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. 2011 Oct 24;286(51):44234–44242. doi: 10.1074/jbc.M111.286195

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Scrapie-inoculated Tg(Δ23–134)/Prn-p^0/0 mice do not develop clinical Illness or histopathology. A, survival was monitored in mice of the following genotypes after scrapie inoculation, with the number of animals indicated in parentheses: Prn-p^0/0 (9), Tg(PrPΔ23–134L)/Prn-p^0/0 (7), Tg(PrPΔ23–134H)/Prn-p^0/0 (9), Prn-p^+/+ (8). Data from RML-inoculated Prn-p^0/0 and Prn-p^+/+ mice shown in Fig. 4 are reproduced here to allow for direct comparison. B, mice were taken for histological analysis at 1 year of age, at which point they remained healthy. Cerebellar sections were stained with hematoxylin and eosin. Scale bar (applicable to all panels) is 1 mm.