FIGURE 1.

Bioinformatic prediction of putative miRNA targeting on PCMT1 transcripts. Prediction was made using three algorithms in combination, as described under ”Experimental Procedures.“ Results with the three approaches were highly consistent (not shown). Only the microRNA with the highest scores are shown. A, putative seed sequence for microRNA 15a and 16–1 at PCMT1 3′ UTR. B, evolutionary conservation of the above PCMT1 seed sequence. Hsa, human; Ptr, chimpanzee; Mml, rhesus; Rno, rat; Eeu, hedgehog; Cfa, dog; Eca, horse; Bta, cow; Dno, armadillo; Laf, elephant; Ete, tenrec; Mdo, opossum; Oan, platypus; Aca, lizard.