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. 2011 Oct 21;30(22):4586–4600. doi: 10.1038/emboj.2011.383

Figure 3.

Figure 3

Jarid1b binds to transcriptional start sites of genes regulating development. (A) Genome-wide binding profiles of Jarid1b in E14 mouse ESCs were determined by ChIP sequencing. Two examples of binding profiles of genes bound by Jarid1b in ESCs are shown. Y-axis denotes number of sequence tag reads. (B) Distribution of Jarid1b peaks upstream of the transcriptional start site (TSS), at the TSS, in intragenic regions, at 3′ ends of genes and in intergenic regions. (C) Mean distribution of tags relative to the TSS (distance in bp). (D) ChIP-qPCR for Jarid1b of genes identified as Jarid1b positive or Jarid1b negative by ChIP-seq in LKO Scr and Jarid1b ESCs. (E) Percentage of H3K27me3, H3K4me2/3 (left/right panel) + H3K27me3, H3K4me2/3 (left/right panel) and unmodified promoters within Jarid1b target genes compared with all genes analysed (Mikkelsen et al, 2007; Mohn et al, 2008). (F) GO term analysis of genes bound by Jarid1b in ESCs. The 12 top scoring categories are presented.