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A limiting role for the RNA localization machinery in axonal regeneration. (Upper schematic) ZBP1 is required for the axonal localization of β-actin, GAP-43, and likely additional mRNAs. (Middle) Introduction of an exogenous mRNA that competes with endogenous transcripts for binding to ZBP1 reduces the supply of endogenous mRNAs to the axon and attenuates axon regeneration after injury. (Lower) Reductions in ZBP1 levels in the neuron have the same effect.
