Table 1.
Studies currently offering clinical data from the NIDDK Central Repository
| Acronym | Study | Conditions | Study type | Biospecimens | Genotype available | Sample sizes |
|---|---|---|---|---|---|---|
| A2ALL | Adult Living Donor Liver Transplantation | Liver disease, End stage liver disease, kidney disease | Retrospective records review | DNA, serum, tissue, whole blood | 819 | |
| AASK | The African American Study of Kidney Disease and Hypertension Study | Kidney disease, Hypertension | Clinical trial | buffy coat, serum, urine | 2802 screened, 1094 randomized | |
| ATN | Acute Renal Failure Trial Network | Kidney disease, End stage kidney disease | Clinical trial | 1124 | ||
| BACH | Boston Area Community Health Study | Urogynecologic symptoms, Incontinence, Interstitial cystitis, Chronic pelvic pain, Prostatitis, Hypogonadism, Sexual dysfunction | Epidemiologic survey | 5506 | ||
| BE-DRI | Behavior Enhances Drug Reduction of Incontinence | Incontinence | Clinical trial | 4043 screened, 307 randomized | ||
| CDS | Comprehensive Dialysis Study | Kidney disease, Dialysis | Prospective cohort study | PBMC, plasma, serum | 1677 | |
| CPCRN | Chronic Prostatitis Collaborative Research Network Cohort Study | Prostatitis, Chronic Pelvic Pain | Prospective cohort study | 488 | ||
| CPCRN RCT #1 | Chronic Prostatitis Collaborative Research Network Clinical Trial | Prostatitis, Chronic pelvic pain | Clinical trial | 272 | ||
| CRISP | Consortium for Radiologic Imaging Studies of PKD | Kidney disease, PKD | Prospective cohort study | DNA, plasma, serum, urine, whole blood | Yes | 241 |
| DPP | Diabetes Prevention Program | Type 2 diabetes, Impaired glucose tolerance | Clinical trial | DNA, Plasma | 3819 | |
| DPT-1 | Diabetes Prevention Trial—Type 1 | Type 1 diabetes, | Clinical trial | DNA, Plasma, Serum | 711 | |
| EDIC | Epidemiology of Diabetes Interventions and Complications | Type 1 diabetes, Coronary heart disease, Kidney disease, Neuropathy, Retinopathy | Longitudinal Follow-up of Participants in DCCT | DNA, Plasma, serum, urine | Yes | 1297 active in 2008a |
| DCCT | The Type 1 Diabetes Control and Complications Trial | Type 1 diabetes, Coronary heart disease, Kidney disease, Neuropathy, Retinopathy | Clinical trial | DNA, Plasma, PBMC, RNA, Serum | 1441 | |
| FIND | Family Investigation of Nephropathy and Diabetes | Type 2 diabetes, Kidney disease | (i) Family-based Linkage analysis, and (ii) genetic case-control study using mapping by admixture linkage disequilibrium (MALD) | DNA, serum, urine, whole blood | Yes | 9031 including family dyads and triads for linkage analysis |
| GoKind | The Genetics of Kidneys in Diabetes | Type 1 diabetes, Kidney disease | Genetic case–control study | DNA, Plasma, serum, urine | Yes | 3079 including both singletons and trios |
| HALT-C | The Hepatitis C Antiviral Long-term Treatment against Cirrhosis | Hepatitis C, Liver disease, Cirrhosis | Clinical trial | tissue | Yes | 1145 |
| HEMO | Hemodialysis Study | Kidney disease, Dialysis | Clinical trial | serum | 1846 | |
| IBD | Inflammatory Bowel Disease Genetics | Inflammatory bowel disease, Crohn’ s disease | Genetic case–control study | DNA, serum, whole blood | Yes | 4761 including cases, controls and triosb |
| ICCTG RCT#1 | Interstitial Cystitis Clinical Trail # 1 | Interstitial cystitis, Chronic pelvic pain | Clinical trial (Pilot Study) | urine | 121 | |
| ICCTG RCT#2 | Interstitial Cystitis Clinical Trail # 2 | Interstitial cystitis, Chronic pelvic pain | Clinical trial | urine | 265 randomized | |
| ICDB | Interstitial Cystitis cohort study | Interstitial cystitis, Chronic pelvic pain | tissue | |||
| LTD | Liver Transplantation Database | Liver disease, End stage liver disease | Prospective cohort study | 916 | ||
| LTD2 | Liver Transplantation Database Follow Up | Liver disease, End stage liver disease | Prospective cohort study | 728 survivors of LTD cohort of 916 | ||
| MDRD | Modification of Diet in Renal Disease | Kidney disease | Two clinical trials | buffy coat, plasma, serum, urine | 585 and 255 | |
| MTOPS | Medical Therapy of Prostatic Symptoms | Benign prostatic hyperplasia, Enlarged prostate | Clinical trial | serum | 3047 | |
| NANS | National Analgesic Nephropathy Study | Kidney disease, End-stage renal disease | Case–control study | c | 240 ESRD cases 206 controls | |
| SISTEr | The Stress Incontinence Surgical Treatment Efficacy Trial | Urinary incontinence, Stress urinary incontinence | Clinical trial | 655 | ||
| T1DGC | Type 1 Diabetes Genetics Consortium | Type 1 diabetes | Genetic case–control study | DNA, plasma, serum | Yes | 14 350, including sib-pairs and trios |
| Virahep-C | Viral Resistance to Antiviral Therapy of Chronic Hepatitis C | Hepatitis C, Liver disease | Clinical trial | DNA, PBMC, plasma, RNA, Serum | 401 |
aSource: www2.bsc.gwu.edu/bsc/oneproj.php?pkey=10 (18 July 2011, date last accessed).
bAs of November 2007; Source: www.niddkrepository.org/niddk/jsp/public/IBD/IBDMetadata.jsp (18 July 2011, date last accessed).
cDigitized CT scans of kidneys are available for 207 EDRD subjects and 26 normal cases.