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. 2011 Nov 4;30(23):4755–4763. doi: 10.1038/emboj.2011.396

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Copyright © 2011, European Molecular Biology Organization

This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial No Derivative Works 3.0 Unported License, which permits distribution and reproduction in any medium, provided the original author and source are credited. This license does not permit commercial exploitation or the creation of derivative works without specific permission.

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NTP binding to ITC-mimicking structures. (A) Superposition of AMPCPP-containing complexes with 4, 5, 6, and 7 nt RNA. Shown are the DNA–RNA hybrids and the AMPCPP (orange) from the front. (B) Unbiased F_o−F_c difference electron density (blue mesh) for AMPCPP in different structures. Maps are contoured at 2.5σ for the 2-nt complex, at 2.2σ for the 4-nt complex, and at 3σ for the 5-, 6-, and 7-nt complexes. (C) Superposition of structures with 6-nt RNA in the absence (DNA and RNA in light blue and light red, respectively) and in the presence of AMPCPP (DNA and RNA in blue and red) reveals a change from the tilted to the standard hybrid conformation upon AMPCPP binding.