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. 2011 Nov 4;30(23):4755–4763. doi: 10.1038/emboj.2011.396

Figure 6.

Figure 6

NTP positions and contacts. (A) Contacts of AMPCPP with active site residues of Pol II in the 6-nt RNA structure. (B) Contacts of the AMPCPP in (A) with the closed trigger loop (magenta). (C) Comparison of AMPCPP substrates in the Pol II 6-nt RNA structure (orange) and in the bacterial RNA polymerase EC (violet) (Vassylyev et al, 2007). (D) Comparison of AMPCPP in the 6-nt RNA Pol II structure (orange) and a GTP in the Pol II EC with a non-reactive RNA lacking the 3′-OH group (yellow) (Wang et al, 2006).