Table 1.
TNFα Promoter Region and LTA SNP Polymorphisms Frequencies in the Control Group and in Patients with LSIL and HSIL.
| SNP Site/Allele Genotype | Control, n (%) | LSIL, n (%) | OR* (95% CI) | HSIL, n (%) | OR† (95% CI) |
| TNFα | |||||
| -163 | |||||
| G | 403 (98.59) | 264 (100.0) | 118 (100.0) | ||
| A | 7 (1.70) | 0 (0.0) | 0 (0.0) | ||
| GG | 198 (96.58) | 132 (100.0) | Reference | 59 (100.0) | Reference |
| GA | 7 (3.14) | 0 (0.0) | — | 0 (0.0) | — |
| Carrier A | 7 (3.14) | 0 (0.0) | — | 0 (0.0) | — |
| -238 | |||||
| G | 403 (98.30) | 264 (100.0) | 118 (100.0) | ||
| A | 7 (1.70) | 0 (0.0) | 0 (0.0) | ||
| GG | 199 (97.07) | 132 (100.0) | Reference | 59 (100.0) | Reference |
| GA | 5 (2.93) | 0 (0.0) | — | 0 (0.0) | — |
| AA | 1 (0.48) | 0 (0.0) | — | 0 (0.0) | — |
| Carrier A | 6 (2.92) | 0 (0.0) | — | 0 (0.0) | — |
| -244 | |||||
| G | 404 (98.53) | 261 (98.86) | 118 (100.0) | ||
| A | 6 (1.46) | 3 (1.13) | 0 (0.0) | ||
| GG | 199 (97.07) | 129 (97.72) | Reference | 59 (100.0) | Reference |
| GA | 6 (2.93) | 3 (2.27) | — | 0 (0.0) | — |
| Carrier A | 6 (2.92) | 3 (2.27) | NS | 0 (0.0) | — |
| -308 | |||||
| G | 387 (94.40) | 250 (94.69) | 115 (97.45) | ||
| A | 23 (5.60) | 14 (5.30) | 3 (2.54) | ||
| GG | 183 (89.26) | 122 (92.42) | Reference | 56 (94.91) | Reference |
| GA | 21 (10.24) | 10 (7.57) | NS | 3 (5.08) | NS |
| AA | 1 (0.48) | 0 (0.0) | — | 0 (0.0) | — |
| Carrier A | 22 (10.73) | 10 (7.57) | NS | 3 (5.08) | NS |
| -376 | |||||
| G | 402 (98.04) | 250 (94.69) | 117 (99.15) | ||
| A | 8 (1.95) | 14 (5.30) | 1 (0.84) | ||
| GG | 197 (96.09) | 119 (90.15) | Reference | 58 (98.30) | Reference |
| GA | 8 (3.90) | 12 (9.09) | 2.48 (0.98–6.25)‡ | 1 (1.69) | — |
| AA | 0 (0.0) | 1 (0.75) | — | 0 (0.0) | — |
| Carrier A | 8 (3.90) | 13 (9.85) | NS | 1 (1.69) | NS |
| -857 | |||||
| C | 304 (74.14) | 186 (70.45) | 83 (70.33) | ||
| T | 106 (25.85) | 78 (29.54) | 35 (29.66) | ||
| CC | 114 (55.60) | 63 (47.72) | Reference | 30 (50.84) | Reference |
| CT | 76 (37.07) | 59 (44.69) | NS | 23 (38.98) | NS |
| TT | 15 (7.31) | 10 (7.57) | NS | 6 (10.16) | NS |
| Carrier T | 91 (44.40) | 69 (52.28) | NS | 29 (49.15) | NS |
| -863 | |||||
| C | 360 (87.80) | 237 (89.77) | 110 (93.22) | ||
| A | 50 (12.19) | 27 (10.22) | 8 (6.77) | ||
| CC | 160 (78.04) | 106 (80.30) | Reference | 52 (88.13) | Reference |
| AC | 40 (19.51) | 25 (18.93) | NS | 6 (10.16) | NS |
| AA | 5 (2.43) | 1 (0.75) | NS | 1 (1.69) | NS |
| Carrier A | 45 (21.95) | 26 (19.70) | NS | 7 (11.87) | NS |
| -1031 | |||||
| T | 345 (84.14) | 223 (84.46) | 102 (86.44) | ||
| C | 65 (15.85) | 41 (15.53) | 16 (13.55) | ||
| TT | 147 (71.70) | 93 (70.45) | Reference | 45 (76.27) | Reference |
| CT | 51 (24.87) | 37 (28.03) | NS | 12 (20.33) | NS |
| CC | 7 (3.41) | 2 (1.51) | NS | 2 (3.38) | NS |
| Carrier C | 58 (28.30) | 29 (29.55) | NS | 14 (23.73) | NS |
| LTA | |||||
| +252 | |||||
| A | 273 (66.58) | 176 (66.66) | 74 (62.71) | ||
| G | 137 (33.41) | 88 (33.33) | 44 (37.28) | ||
| AA | 92 (44.87) | 60 (45.45) | Reference | 21 (35.59) | Reference |
| AG | 89 (43.41) | 56 (42.42) | NS | 32 (54.23) | NS |
| GG | 24 (11.70) | 16 (12.12) | NS | 6 (10.16) | NS |
| Carrier G | 113 (55.13) | 72 (54.55) | NS | 38 (64.40) | NS |
NS indicates that the P value is not significant.
*
Odds ratio calculated by comparing LSIL versus control.
†
Odds ratio calculated by comparing HSIL versus control.
‡
P < .05.