Table 2.

The mean scores and 95% confidence intervals (CIs) for the symptoms pain, fatigue, vomiting, nausea, diarrhea, and constipation^*

Clinical symptom	Patient score (EORTC QLQ-C30)†, mean (95% CI)	Clinician score (NCI-CTCAE)‡, mean (95% CI)
Pain	2.31 (2.26 to 2.36)	2.13 (2.07 to 2.18)
Fatigue	2.10 (2.05 to 2.15)	1.36 (1.33 to 1.40)
Vomiting	1.11 (1.08 to 1.14)	1.18 (1.15 to 1.21)
Nausea	1.38 (1.35 to 1.41)	1.20 (1.16 to 1.24)
Diarrhea	1.27 (1.23 to 1.31)	1.10 (1.08 to 1.12)
Constipation	1.50 (1.44 to 1.56)	1.11 (1.09 to 1.14)

^*For purposes of comparison, we considered each of the following pairs to be identical responses: EORTC QLQ-C30 score 1 vs NCI-CTCAE score 0; EORTC QLQ-C30 score 2 vs NCI-CTCAE score 1; EORTC QLQ-C30 score 3 vs NCI-CTCAE score 2; EORTC QLQ-C30 score 4 vs NCI-CTCAE scores 3 and 4 combined. EORTC QLQ-C30 = European Organization for Research and Treatment of Cancer's Quality of Life core questionnaire; NCI-CTCAE = National Cancer Institute's Common Terminology Criteria for Adverse Events.

^†In the EORTC QLQ-C30 questionnaire, the patient rated his or her symptoms on a 4-point ordinal scale in which a score of 1 meant “not at all,” a score of 2 meant “a little,” a score of 3 meant “quite a bit,” and a score of 4 meant “very much.”

^‡In the NCI-CTCAE scoring, the clinician rated the patient's symptoms on a 5-point scale: a score of 0 meant “none or normal,” a score of 1 meant “mild,” a score of 2 meant “moderate,” a score 3 meant “severe,” and a score of 4 meant “life threatening or disabling.”