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. 2011 Dec 20;6(12):e28293. doi: 10.1371/journal.pone.0028293

Figure 2. Proposed role of miR-451 in the regulation of LKB1 signaling in response to fluctuating glucose.

Figure 2

miR-451 levels determine cell migration or proliferation in response to glucose (blue triangle on the left). (A) Low glucose level reduces miR-451 and leads to upregulation of AMPK and enhanced cell motility. (B) Normal glucose level upregulates miR-451, which in turn leads to increased proliferation and decreased cell migration by inhibiting CAB39-LKB1-AMPK pathway. Schematic components of miR-451 and the CAB39/LKB1/AMPK complex is represented by modules ‘M’ (box with red dotted line) and ‘A’ (box with blue dotted line) in our theoretical framework. Blue arrows on the right indicate the switching behavior between a migratory mode in (A) and the proliferative state in (B) in response to fluctuating glucose.