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. 2011 Dec 20;6(12):e28293. doi: 10.1371/journal.pone.0028293

Figure 3. A simplified model of the network shown in Figure 2.

Figure 3

Two key molecules, miR-451 and AMPK complex, are represented by Inline graphic and Inline graphic respectively. The dynamics of miR451 includes input from glucose (Inline graphic), decay (Inline graphic), and autocatalytic increase. AMPK complex is induced by source (Inline graphic), and undergoes autocatalytic increase with natural decay (Inline graphic). In addition, there are mutual inhibition mechanisms between Inline graphic and Inline graphic.