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. 2011 Dec 20;6(12):e28293. doi: 10.1371/journal.pone.0028293

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Kim et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Effect of glucose deprivation on miR-451 expression levels. In [2], miR-451 level was reduced by 21% for different cell lines (U251, LN229) after cells are cultured for 24 hr in normal (+, glucose or reduced glucose (−, glucose 0.3 g/l). Simulation results (red) are in good agreement with experimental results (blue; U251 cell line) from [2]. Y-axis in the figure is the relative miR-451 concentration for high (glucose+; dimensionless value in simulation) and low (glucose−, glucose−, in simulation) level of glucose in the medium.

Inline graphic — Effect of glucose deprivation on miR-451 expression levels. In [2], miR-451 level was reduced by 21% for different cell lines (U251, LN229) after cells are cultured for 24 hr in normal (+, glucose or reduced glucose (−, glucose 0.3 g/l). Simulation results (red) are in good agreement with experimental results (blue; U251 cell line) from [2]. Y-axis in the figure is the relative miR-451 concentration for high (glucose+; dimensionless value in simulation) and low (glucose−, glucose−, in simulation) level of glucose in the medium.