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. Author manuscript; available in PMC: 2012 Dec 20.
Published in final edited form as: Acc Chem Res. 2011 Oct 25;44(12):1320–1328. doi: 10.1021/ar2001149

Figure 3. Crystal structure of IRP1 as c-aconitase and complexes with IRE-RNA.

Figure 3

A. Differences in protein domain positions between c-aconitase and IRP1:IRE-RNA complex. Left: FeS-apo-IRP; Right: IRE-RNA/IRP. RNA-magenta; protein- blue, green, red, yellow. B. Close up of the protein–RNA contacts at the RNA triloop; C. Close-up of the protein–RNA contacts at the RNA bulge C8. (From ref. 12, with permission).