Table 1.

Baseline Characteristics

	Hypothyroidism	Hyperthyroidism	p-value
	Mean ± SD	Mean ± SD
Number of subjects	15	12
Age (yr)	7.9 ± 2.6	8.0 ± 2.2	0.90
Bone age (yr)	6.8 ± 2.2	9.5 ± 1.9	0.002
Gender (% female)	93%	75%	0.29
Height SDS	−0.61 ± 1.09	1.58 ± 0.84	<0.0001
Height velocity (cm/yr)	3.5 ± 2.0	10.0 ± 3.2	<0.0001
TSH (mU/L)	107 (31.3,150)*	0.03 (0.02, 0.03)*	0.0002
T3 (nmol/L)	1.61 ± 0.83	9.1 ± 3.61	<0.0001
T4 (nmol/L)	38.6 ± 29.6	248.4 ± 63.1	<0.0001
CNP (pmol/L)	1.1 (0.9,1.6)*	1.8 (1.7, 2.2)*	0.02
CNP SDS	−1.08 (−1.48-0.10)*	0.65 (0.15,1.31)*	0.02
NTproCNP (pmol/L)	35.3 (29.2,48.1)*	58.1 (37.8, 76.7)*	0.02
NTproCNP SDS	0.03 (−0.67, 0.90)*	2.28 (1.21,3.51)*	0.03
NTproCNP:CNP	32.2 ± 8.6	31.3 ± 8.7	0.81
BSAP (mcg/L)	59.6 ± 29.3	102.9 ± 21.3	0.0003
IGF-I (nmol/L)	16.6 ± 6.0	18.2 ± 7.0	0.54

Note: Numbers are mean ± SD, except those marked with an asterix, which are median with interquartile range. Significant values in are in bold.