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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Crit Rev Oncog. 2011;16(1-2):25–36. doi: 10.1615/critrevoncog.v16.i1-2.40

Figure 2. Multi-step model of leukemogenesis in Down syndrome.

Figure 2

A) Sequential acquisition of known genetic abnormalities and their role in the evolution of DS-AMKL. B) Aberrant signaling pathways implicated in the pathogenesis of DS-AMKL. The chromosome 21 specific genes that appear to have a functional impact in these pathways are highlighted in blue.