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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Crit Rev Oncog. 2011;16(1-2):37–46. doi: 10.1615/critrevoncog.v16.i1-2.50

Figure 1. The regulation of CREB activation.

Figure 1

A variety of extracellular stimuli can promote CREB phosphorylation and activation through different kinases. CREB can then interact with coactivators to promote the transcription of CREB responsive genes. CREB target genes have been shown to mediate effects including cellular proliferation, survival, differentiation, immune response, and hematopoiesis.