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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Crit Rev Oncog. 2011;16(1-2):3–12. doi: 10.1615/critrevoncog.v16.i1-2.20

FIGURE 1. Phosphorylation regulates the tumor suppressor function of Ikaros.

FIGURE 1

CK2 kinase directly phosphorylates and functionally inactivates Ikaros, while PP1 phosphatase counteracts this process. Functional inactivation of Ikaros by CK2 kinase promotes leukemogenesis.