Table 2.
Associations of PALB2 tagging SNPs with melanoma in melanoma-prone families with CDKN2A mutations
| SNPs | All families (n=23) | Families with PC or PC-related mutations (n=11) | ||
|---|---|---|---|---|
| OR (95% CI)1 | p1 | OR (95% CI) 1 | p1 | |
| rs240745 | 0.58 (0.29–1.19) | 0.14 | 0.73 (0.25–2.12) | 0.57 |
| rs240744 | 1.42 (0.59–3.43) | 0.44 | 1.17 (0.39–3.53) | 0.78 |
| rs12162020 | 0.72 (0.33–1.61) | 0.43 | 1.27 (0.44–3.66) | 0.66 |
| rs420259 | 1.30 (0.73–2.32) | 0.37 | 1.60 (0.74–3.48) | 0.24 |
| rs513313 | 1.66 (0.65–4.24) | 0.29 | 1.23 (0.34–4.45) | 0.75 |
| rs16940342 | 1.14 (0.59–2.23) | 0.69 | 1.14 (0.52–2.52) | 0.74 |
| rs8058061 | 0.76 (0.18–3.26) | 0.71 | 1.30 (0.25–6.77) | 0.76 |
| rs0843812 | 0.58 (0.23–1.47) | 0.25 | 0.73 (0.15–3.55) | 0.70 |
| rs17806253 | 0.74 (0.34–1.57) | 0.43 | 0.71 (0.24–2.12) | 0.54 |
| rs34514 | 0.93 (0.49–1.75) | 0.82 | 1.02 (0.40–2.61) | 0.96 |
| rs34513 | 0.88 (0.48–1.61) | 0.68 | 1.24 (0.50–3.04) | 0.64 |
1
ORs and P values are obtained from likelihood ratio test in conditional logistic regression with melanoma as the outcome variable adjusting for age, gender, and CDKN2A status.