Table 2.

Sequence-based neutrality tests across the 27 genes encoding the IFNs and their receptors

	AFRICA				EUROPE				ASIA
Gene	TD	D	F	Hn	TD	D	F	Hn	TD	D	F	Hn
TYPE I IFNs
IFNA1	−0.15	0.09	0.00	−1.06	−1.59†	−0.82	−1.31	−3.20*	−0.97	−0.65	−0.91	−3.07*
IFNA2	−1.42	−0.01	−0.64	−0.94	−0.02	0.41	0.31	0.90	0.54	0.12	0.31	0.20
IFNA4	−0.88	−1.57	−1.56	−0.69	0.28	−0.97	−0.61	−2.59*	1.24	−0.68	0.04	0.43
IFNA5	−0.93	−0.65	−0.89	0.06	−1.09	−2.42†	−2.33*†	−0.66	0.19	−0.42	−0.25	0.40
IFNA6	−0.92	0.28	−0.16	0.60	−0.22	−0.31	−0.33	0.67	0.31	−0.07	0.07	0.45
IFNA7	−1.78	−1.55	−1.94	−0.96	−1.32	−1.55	−1.74	0.27	−0.58	0.12	−0.14	−1.14
IFNA8	−0.47	−0.11	−0.29	0.72	−0.72	−2.21†	−1.99	0.47	−0.33	−0.49	−0.52	0.85
IFNA10	−0.39	1.11	0.62	−1.81*	−1.20	−0.59	−0.98	−1.95	0.86	−1.59	−0.83	−0.41
IFNA13	0.10	1.36*†	1.09*†	0.35	−0.63	−0.65	−0.77	−1.00	−0.17	−3.01*†	−2.38*†	0.09
IFNA14	−1.70	−1.80	−2.10	−0.66	−1.37	−2.83*†	−2.77*†	−0.94	0.68	−0.31	0.01	0.28
IFNA16	−1.14	0.33	−0.31	−3.40*	−0.96	1.28	0.51	−4.75**†	0.67	0.27	0.49	−0.06
IFNA17	0.21	0.68*†	0.60†	−0.64	−0.06	−0.68	−0.53	−1.50	1.51	−0.82	0.07	0.27
IFNA21	−1.12	−2.37	−2.28	0.16	0.62	0.28	0.47	0.42	0.51	0.41	0.53	−0.30
IFNB1	−1.38	−1.06	−1.41	-0.79	−0.28	−1.25	−1.09	−1.00	−0.08	−0.42	−0.36	−0.65
IFNE	−0.51	−0.35	−0.49	0.69	−0.29	−0.42	−0.45	−0.03	0.19	−1.02	−0.71	0.08
IFNK	−0.89	−0.65	−0.89	0.08	−0.90	−1.52	−1.54	−0.53	−0.84	−3.25*†	−2.81*†	−0.99
IFNW1	−1.07	−1.14	−1.33	0.61	−1.36	−3.45**†	−3.20**	0.36	−0.33	−0.82	−0.77	0.76
IFNAR1	−0.82	−0.77	−0.95	-0.27	0.46	−0.43	−0.11	1.10	−0.05	−3.50**†	−2.66*†	0.75
IFNAR2	−0.99	−2.58	−2.31	-0.71	1.03	−0.39	0.19	−0.10	−0.01	−1.76	−1.28	−0.94
TYPE II IFN
IFNG	−1.60	−1.39	−1.76	-2.10*	0.34	−1.02	−0.65	−0.42	0.70	0.12	0.37	−0.11
IFNGR1	−1.44	−2.13	−2.23	-0.26	0.27	−2.02	−1.43	0.44	−0.37	−0.95	-0.88	0.55
IFNGR2	−1.13	−3.09	−2.77	-0.37	0.39	−1.63	−1.05	−0.54	−0.73	−4.08**†	−3.36**†	−0.92
TYPE III IFNs
IL28A	−0.95	−1.99	−1.90	-2.50	−0.93	−1.33	−1.42	−0.05	−1.92*††	−3.39**†	−3.42**†	−0.89
IL28B	−0.18	1.18**†	0.75†	0.42	0.66	−1.06	−0.48	−1.73	−1.57*†	−3.01*†	−2.94*†	−2.35*
IL29	−1.00	−2.00	−1.95	-0.33	−1.72*†	−3.81**††	−3.68**††	−1.41	−1.71*††	−0.86	−1.36	−1.56
IL28RA	−0.64	−0.93	−0.97	-0.24	−0.20	−1.52	−1.22	−0.28	-0.83	−2.63*†	−2.33*†	−0.19
IL10RB	−0.32	−0.63	−0.60	−0.66	1.50	−0.55	0.26	0.28	0.53	−1.32	−0.74	−0.35

TD, Tajima’s D; D, Fu & Li’s D*; F, Fu & Li’s F*; Hn, normalized Fay && Wu’s H. **/*, P ≤ 0.01 and ≤ 0.05, respectively, according to the model of (Voight et al., 2005); ††/†, P ≤ 0.01 and ≤ 0.05, respectively, according to the model of (Laval et al., 2010).