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. 2011 Dec 19;208(13):2705–2716. doi: 10.1084/jem.20110547

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© 2011 Sotolongo et al.

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Figure 1. — TRIF deficiency results in greater mortality and higher susceptibility to bacterial dissemination in the Y. enterocolitica infection model. WT and Trif^Lps2 mice were orally infected with 2 × 10⁷ CFU Y. enterocolitica. (A) Weight loss in WT and Trif^Lps2 mice during Y. enterocolitica infection (n = 8 each; *, P < 0.05). Combined data from four independent experiments are shown. Error bars, SEM. (B) Kaplan Meier survival curves for infected WT (n = 11) and Trif^Lps2 mice (n = 15). Combined data from four independent experiments are shown (*, P < 0.01). (C) H&E staining of the spleen and liver taken 48 h after infection. Arrowheads indicate abscesses. Representative pictures from six mice of each genotype. Bars, 100 µm. (D) Y. enterocolitica titers in the spleens, MLNs, and PPs of individual infected WT and Trif^Lps2 mice taken 48 h after infection. Pooled data from three independent experiments are shown (n = 6 each; *, P < 0.05). Horizontal bars indicate mean.