Table 1.
Structural data of the ligand-induced microtubules
| Compound | J01 (nm−1)∗ | Mean helical radius (nm)† | Average protofilament number‡ |
|---|---|---|---|
| Baccatin III | 0.0595 ± 0.0006 | 10.3 ± 0.2 | 11.3 ± 0.3 |
| Cephalomannine | 0.0535 ± 0.0002 | 11.4 ± 0.1 | 12.6 ± 0.1 |
| Paclitaxel | 0.0518 ± 0.0004 | 11.8 ± 0.1 | 13.0 ± 0.1 |
| Docetaxel | 0.0480 ± 0.0005 | 12.7 ± 0.2 | 14.0 ± 0.2 |
| Chitax-1 | 0.0455 ± 0.0002 | 13.4 ± 0.1 | 14.8 ± 0.1 |
| Chitax-4 | 0.0443 ± 0.0008 | 13.8 ± 0.3 | 15.2 ± 0.3 |
| Chitax-5 | 0.0435 ± 0.0005 | 14.0 ± 0.1 | 15.5 ± 0.1 |
| Chitax-11 | 0.0498 ± 0.0003 | 12.2 ± 0.1 | 13.5 ± 0.1 |
| Chitax-12 | 0.0501 ± 0.0003 | 12.2 ± 0.1 | 13.4 ± 0.1 |
| Chitax-13 | 0.0518 ± 0.0004 | 11.8 ± 0.1 | 13.0 ± 0.1 |
| Chitax-14 | 0.0493 ± 0.0002 | 12.4 ± 0.1 | 13.6 ± 0.1 |
| Chitax-15 | 0.0504 ± 0.0003 | 12.1 ± 0.1 | 13.3 ± 0.1 |
| Chitax-17 | 0.0501 ± 0.0003 | 12.2 ± 0.1 | 13.4 ± 0.1 |
| Chitax-18 | 0.0543 ± 0.0004 | 11.2 ± 0.1 | 12.4 ± 0.1 |
| Chitax-19 | 0.0476 ± 0.0003 | 12.8 ± 0.1 | 14.1 ± 0.1 |
| Chitax-20 | 0.0503 ± 0.0004 | 12.1 ± 0.1 | 13.4 ± 0.1 |
| Chitax-21 | 0.0513 ± 0.0006 | 11.9 ± 0.2 | 13.1 ± 0.3 |
| Chitax-40 | 0.0521 ± 0.0005 | 11.7 ± 0.2 | 12.9 ± 0.2 |
| Flutax-1 | 0.0460 ± 0.0002 | 13.3 ± 0.1 | 14.6 ± 0.1 |
| Flutax-2 | 0.0460 ± 0.0002 | 13.3 ± 0.1 | 14.6 ± 0.1 |
| Hexaflutax | 0.0446 ± 0.0003 | 13.7 ± 0.1 | 15.1 ± 0.1 |
∗
Values indicate the position of the J01 maxima in the scattering profiles obtained from three independent measurements. Fitting of the peaks was done using the curve-fitting software tool TableCurve2D 5.01 (Systat Software, Richmond, CA). The error is the error of the best fit.
†
Values are the helical radii estimated from the positions of the first subsidiary maxima of the J0 Bessel function J01 = 1.22/2R (26).
‡
Calculated from the mean helical radius and the microtubule interprotofilament spacing (5.7 nm) (14).