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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Cell. 2011 Apr 1;145(1):145–158. doi: 10.1016/j.cell.2011.03.012

Figure 4. Reversible GFP-marked DOX-dependent knockdown in live animals.

Figure 4

(A) GFP and bioluminescent images of E17.5 TG-luc.1309;R26-rtTA;Rosa-Luciferase (shluc/R/RL) embryos sacrificed from pregnant females treated with or without DOX.

(B) Relative GFP intensity and (C) bioluminescence between shluc/RL and shluc/R/RL embryos. Error bars represent SEM, n=7.

(D) In vivo bioluminescent time course imaging of TG-luc.1309;R26-rtTA;Rosa-Luciferase (shluc/R/RL) triple transgenics and controls. Animals were treated with or without DOX for 4 days, then removed from treatment.

See also Figure S4