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. Author manuscript; available in PMC: 2011 Dec 21.
Published in final edited form as: Alcohol. 2008 Sep 11;42(7):525–539. doi: 10.1016/j.alcohol.2008.06.006

TABLE 1.

Drug-induced F-actin depolymerization in primary cultured cerebellar granule cells. (Values are mean ± s.e.m.)

Pearl Number Pearl / Neurite Fiber Length
(μm / pixel)		 Fiber Breadth
(μm / pixel)
Control 28.0±7.1 2.5±0.4 3.9±0.25 2.3±0.1
Ethanol with wash 33.3±11.1 2.7±0.4 3.8±0.2 2.5±0.15
Latrunculin A with wash 30.3±8.8 2.9±0.9 4.0±0.4 2.3±0.3
Ethanol 50.0±7.1 5.2±2.4**a 4.0±0.6 2.3±0.1
Latrunculin A 101±10.4***b 4.2±0.4** 3.8±0.05 2.4±0.1
DMSO 46.0±11.2 3.3±0.5 3.8±0.15 1.4±0.1

Control, no drug treatment; Ethanol with wash, removal of 100 mM ethanol after a 2.5 min exposure time by a 30 s wash with normal external; Latrunculin A with wash, removal of 20 ng / ml Latrunculin A after a 2.5 min exposure time by a 30 s wash with normal external; ethanol, 30 s exposure of 100 mM ethanol; Latrunculin A, 30 s exposure of 20 ng / ml latrunculin A; DMSO, 30 s exposure of 0.002 % DMSO (vehicle control). Significant values are indicated: P ≤ 0.01** or P ≤ 0.001*** compared to control values and P ≤ 0.05a compared to ethanol with wash and P ≤ 0.001b compared to latrunculin A with wash.