Table 3.

Astro’s task force consenses tables for: patients approved as “Suitable”, “Cautionary” or “Unsutiable” candiates for APBI

	Patients “Suitable” for APBI if all criteria are present	“Cautionary” group: any of these criteria should invoke caution and concern when considering APBI	Patients “Unsuitable” for APBI outside of a clinical trial if any these criteria are present
Factor	Criterion	Criterion	Criterion
Patient factors
Age	≥60 y	50–59 years	<50 years
BRCA 1/2 mutation	Not present		Present
Pathologic factors
Tumor size	≤2 cm	2.1–3.0 cm	>3 cm
T stage	T1	T0 or T2	T3-4
Margins	Negative by at least 2 mm	Close (<2 mm)	Positive
Grade	Any
LVSI	No	Limited/focal	Extensive
ER status	Positive	Negative†
Multicentricity	Unicentric only		Present
Multifocality	Clinically unifocal with total size ≤2.0 cm‡	Clinical unifocal with total size 2.1–3.0 cm ‡	If microscopically multifocal >3 cm in total size or if clicnically multifocal
Histology	Invasive ductal or other favorable subtypes§	Invasive lobular
Pure DCIS	Not allowed	≤3 cm	If >3 cm in size
EIC	Not allowed	≤3 cm	If >3 cm in size
Associated LCIS	Allowed
Nodal factors
N stage	pNO (¡-, ¡+)		pN1, pN2, pN3
Nodal surgery	SN Bx or ALND׀׀		None performed
Treatment factors
Neoadjuvant therapy	Not allowed		If used

Adaptation From: Smith BD, Arthur DW, Buchholz, TA, et al. “Accelerated partial breast consensus statement from the American Society for Radiation Oncology (ASTRO).” Int J Radiat Oncol Biol Phys 74, no. 4 (July 2009): 987–1001