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Prefrontal Pathways for modulating amygdalar output to autonomic regions. Adapted with permission from (Barbas & Zikopoulos, 2006). The excitatory OFC projections to the intercalated masses (IM) (path a) leads to disinhibition of the hypothalamus by removing the central nucelus’s tonic inhibition of the hypothalamus (path b). The medial PFC projects both directly to the hypothalamus (path c) and indirectly (paths dl,d′) through the basolateral nucleus (BLmc & BLpc).
