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. 2011 Dec 21;6(12):e28670. doi: 10.1371/journal.pone.0028670

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Hu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) The CRPC LTL-313 model showed androgen deprivation induced more abundant expression of EMT markers in a cluster of cells within the tumor region, as revealed by QD labeling of EpCAM, N-Cad, and RANKL. (B) Similar EMT biomarkers were detected in a clinical primary prostate cancer specimen (Gleason score 6; 3+3) with documented bone metastasis. M denotes cells that completed EMT and E/M indicates cells undergoing partial EMT. ×400.