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. 2011 Dec 21;6(12):e28908. doi: 10.1371/journal.pone.0028908

Figure 6. After saphenous nerve injury GFRα2-positive neurons down-regulated GFRα2 and expressed GFRα3.

Figure 6

In naïve mice, IB4-488-back-labeled neurons were immunopositive for GFRα2 (A , B , D ; arrows), but not GFRα3 (E , F , H ; arrows). No ATF3 expression was seen following IB4-488 injections in naïve mice (C , G ; arrows). One d after saphenous nerve lesion, IB4-488-back-labeled neurons expressed ATF3 (I , K , M , O ; arrows), however, GFRα2 expression in IB4-back-labeled neurons was decreased (I , J ; arrows). GFRα3 expression was not seen in IB4-488-labeled neurons 1 d post-transection (M , N , P ; arrows). 6 d after saphenous nerve lesion, IB4-488-back-labeled neurons expressed ATF3 (Q , S , U , W ; arrows) and GFRα3 (U , V , X arrows), but not GFRα2 (Q , R , T ; arrows). Scale bar = 50 µm.