Table 3. Allele frequency and genotypes of the three SNPs in myopia cases and healthy controls. Myopia was classified as early onset high myopia and complex myopia.
| SNPs | Allele (A/B) | Classification of subjects | Number of subjects | MAF | Genotype | p value* | OR | 95%CI | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |
|
|
|
|
|
A/A |
A/B |
B/B |
Allele |
Genotype |
|
|
|
rs2839471 |
C/T |
myopia |
complex (−10.00D≤S≤-4.00D) |
1255 |
0.489 |
293 |
641 |
321 |
0.393 |
0.266 |
1.052 |
0.937–1.181 |
| |
|
|
early onset (S≤-6.00D) |
563 |
0.472 |
116 |
300 |
147 |
0.838 |
0.131 |
0.985 |
0.852–1.139 |
| |
|
|
complex+early onset |
1818 |
0.484 |
409 |
941 |
468 |
0.582 |
0.151 |
1.031 |
0.926–1.148 |
| |
|
healthy control |
−0.50D≤SE≤+2.00D |
1052 |
0.476 |
248 |
506 |
298 |
|
|
|
|
|
rs577948 |
A/G |
myopia |
complex (−10.00D≤S≤-4.00D) |
1255 |
0.494 |
302 |
665 |
288 |
0.307 |
0.269 |
1.062 |
0.946–1.193 |
| |
|
|
early onset (S≤-6.00D) |
563 |
0.491 |
123 |
307 |
133 |
0.973 |
0.282 |
1.003 |
0.867–1.159 |
| |
|
|
complex+early onset |
1818 |
0.499 |
425 |
972 |
421 |
0.439 |
0.207 |
1.043 |
0.937–1.162 |
| |
|
healthy control |
−0.50D≤SE≤+2.00D |
1052 |
0.49 |
251 |
530 |
271 |
|
|
|
|
|
rs11218544 |
G/T |
myopia |
complex (−10.00D≤S≤-4.00D) |
1255 |
0.401 |
200 |
607 |
448 |
0.032 |
0.098 |
1.14 |
1.012–1.284 |
| |
|
|
early onset (S≤-6.00D) |
563 |
0.382 |
83 |
264 |
216 |
0.515 |
0.771 |
1.051 |
0.905–1.220 |
| |
|
|
complex+early onset |
1818 |
0.395 |
283 |
871 |
664 |
0.061 |
0.17 |
1.112 |
0.995–1.242 |
| healthy control | −0.50D≤SE≤+2.00D | 1052 | 0.37 | 142 | 495 | 415 | ||||||
Note: MAF=minor allele frequency; S=spherical refraction; SE=spherical equivalent. *P value was calculated by chi-square test between myopia and normal control.