Table 2.

Fractional anisotropy differences between unaffected relatives of patients with major depressive disorder and controls^*

			MNI coordinates
Region†	Voxels	p value‡	x	y	z
Body–splenium of corpus callosum	261	0.039	9	−30	24
Body of corpus callosum	62	0.046	−11	−28	26
Body of corpus callosum (left IFO, anterior thalamic radiation)	158	0.041	−27	−45	21
Left posterior corona radiate (left corticospinal tract)	95	0.045	−26	−24	25
Left post- and precentral gyrus (left SLF)	71	0.045	−48	−6	21
Left external capsule (left IFO)	20	0.049	−33	−10	6

IFO = inferior fronto-occipital fasciculus; MNI = Montreal Neurological Institute; SLF = superior longitudinal fasciculus; UHR = unaffected relatives of patients with major depressive disorder.

^*The table shows regions with increased fractional anisotropy values for the UHR compared with the control group.

^†The Harvard-Oxford Structural Atlas and ICBM-DTI-81 white-matter labels atlas were used for region identification.³⁹

^‡The p values, family-wise error–corrected for multiple testing across the whole brain fibre tracts, are < 0.05 in all participants.