Table I. Development of AA in 1MOG244.1 mice.
The indicated numbers of 1MOG244.1 or control OT-1 TCR retrogenic mice were monitored for clinical signs of alopecia. Time to initial disease, to alopecia universalis, and number of disease relapses, indicated by a change in disease score =1 is listed. AA was not observed in the OT-1 mice. NA, not applicable.
| Retrogenic TCR |
Mice (No.) |
Time to score ≥1 (d) | Time to score =5 (d) | Number of relapses | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | Median | Range | Mean | Median | Range | Mean | Median | Range | Maximal score |
||
| 1MOG244.1 | 20 | 58±16 | 53 | 38-118 | 139±4 | 140 | 132-143 | 2.7±1.1 | 3 | 0-5 | 5±0 |
| OT-1 | 10 | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0±0 |