Table 3.

Summary of the functions of genes found to be associated with SVG injury

Gene	Function
PDGFA	Angiogenic Induces Neointimal Hyperplasia Possible role in vessel sclerosis
EGF	Stimulates wound healing at endothelium SMC proliferation and invasion
CXCL2	Leukocyte recruitment / Chemotaxis Angiogenic
ITGAV	Mediate cell-cell adhesive interactions Interaction with MMP1 (ITGA2)
HSP90AA1	Protective functions in context of cellular stress Positive modulator of eNOS
IL-1B	Pro-inflammatory Mediates intimal hyperplasia
IL-7	Lymphangiogenesis

Definition of abbreviations and alternative nomenclature for each gene/gene product. PDGFA – Platelet Derived Growth Factor subunit A, PDGF-A, PDGF-1; EGF=Epithelial Growth Factor; CXCL2 – Chemokine (C-X-C-motiff) Ligand 2, ITGAV= integrin alpha V, CD51; HSP90AA1= heat shock protein (HSP) 90kDa alpha (cytosolic) class A member 1, HSP 90-alpha; IL-1B=Interleukin 1-beta; IL-7=Interleukin 7; eNOS=endothelial Nitric Oxide Synthase; MMP – Matrix Metalloproteinase.