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Ultrastructural alterations in the diabetic ON. Transverse sections of the distal ON from a control rat (A) and from a rat after 6 weeks of diabetes (B) are shown. In diabetic animals, clear alterations in the myelin sheaths of larger axons are observed. Note also the presence of lamellar bodies (arrows). Shown are images representative of four animals per group. Scale bar = 2 μm.
