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. 2011 Nov 20;175(1):11–21. doi: 10.1093/aje/kwr272

Table 5.

Associations of the Most Statistically Significant Gene × Environment Interactions and Overlapping Interactions With Body Mass Indexa, by Race/Ethnicity, Southern Community Cohort Study, 2002–2009

Population and Gene Chromosome Gene-Environment Interaction Base Pair Position Minor Allele Minor Allele Frequency βb 95% Confidence Interval P Value
African Americans
    HTR2C X rs17095676 × cigarette smoking (current) 113776514 A 0.18 −0.073 −0.119, −0.028 0.001
    ADIPOR1 1 rs6672643 × cigarette smoking (current) 201167175 G 0.26 −0.070 −0.112, −0.028 0.001
    ADIPOR1 1 rs6672643 × cigarette smoking (pack-years) 201167175 G 0.26 −0.003 −0.005, −0.001 1.44 × 10−4
    PPARGC1A 4 rs4619879 × alcohol consumption 23443974 C 0.46 0.001 0.001, 0.001 3.75 × 10−5
    IL6 7 rs2069824 × dietary energy intake 22731757 G 0.12 −0.006 −0.010, −0.003 3.00 × 10−4
    PPARA 22 rs7284616 × physical activity 45020136 A 0.19 0.002 0.001, 0.003 7.05 × 10−5
    INSIG2 2 rs17047728 × time spent sitting 118555487 A 0.14 0.008 0.004, 0.013 4.46 × 10−4
    LEPR 1 rs6697315 × time spent sleeping 65766144 G 0.38 0.016 0.008, 0.023 9.20 × 10−5
Caucasians
    INSR 19 rs11667110 × cigarette smoking (current) 7087609 C 0.32 0.074 0.031, 0.118 7.21 × 10−4
    IGFBP3 7 rs6670 × smoking (pack-years) 45918779 T 0.23 −0.002 −0.002, −0.001 6.52 × 10−4
    LEPR 1 rs17127677 × alcohol consumption 65730862 A 0.14 0.001 0.000, 0.001 0.001
    GHSR 3 rs9819506 × dietary energy intake 173652798 A 0.30 −0.006 −0.009, −0.003 1.87 × 10−4
    ADIPOR 1 rs12045862 × physical activity 201183429 A 0.26 0.002 0.001, 0.003 0.001
    PPARG 3 rs709157 × time spent sitting 12437024 A 0.32 −0.006 −0.01, −0.002 0.001
    PPARG 3 rs1175540 × time spent sitting 12440243 A 0.36 −0.006 −0.009, −0.002 0.001
    GHRL 3 rs1617161 × time spent sleeping 10311853 A 0.11 −0.030 −0.047, −0.013 5.08 × 10−4

Abbreviations: ADIPOR1, adiponectin receptor 1; GHRL, ghrelin precursor; GHSR, growth hormone secretagogue receptor isoform 1a; HTR2C, 5-hydroxytryptamine (serotonin) receptor 2C; IGFBP3, insulin-like growth factor binding protein 3; IL6, interleukin 6 (interferon, beta 2); INSIG2, insulin-induced protein 2; INSR, insulin receptor; LEPR, leptin receptor isoform 3; PPARA, peroxisome proliferator-activated receptor A; PPARGC1A, peroxisome proliferator-activated receptor G coactivator 1; PPARG, peroxisome proliferator-activated receptor G; rs, reference SNP; SNP, single nucleotide polymorphism.

a

Weight (kg)/height (m)2.

b

Beta coefficient from the generalized linear model.