Table 6.
Randomized controlled trials evaluating the therapeutic efficacy of Vitamin E in NASH
| Author | Year | N | Intervention | Comparator | Duration (months) | Histologic improvement | ||
|---|---|---|---|---|---|---|---|---|
| Steatosis | Inflammation | Fibrosis | ||||||
| Sanyal26 | 2010 | 247 | Vitamin E or Pioglitazone | Placebo | 24 | + | + | − |
| + | + | − | ||||||
| Dufour136 | 2006 | 48 | Vitamin E + UDCA | UDCA + Placebo or Placebo only | 24 | + | − | − |
| Sanyal129 | 2004 | 20 | Vitamin E + Pioglitazone | Vitamin E | 6 | + | + | |
| Harrison134 | 2003 | 49 | Vitamin E + Vitamin C | Placebo | 6 | − | + | |
UDCA, ursodeoxycholic acid; NASH, non-alcoholic steatohepatitis.