Table 2.

Summary of XEN-D0501 pharmacokinetic parameters in fasted and fed conditions

Parameter	5 mg XEN-D0501 fasted (n = 16)	5 mg XEN-D0501 fed (n = 16)	Ratio of adjusted least squares means (90% CI)
tmax (h) median (range)	1.50 (0.50–3.00)	3.00 (1.00–6.00)	NA
Cmax (ng ml−1) mean (CV%)†	77.9 (34%)	62.8 (68%)	80.62 (58.39, 111.31)
AUC(0,tlast) (ng ml−1 h) mean (CV%)†	347 (45%)	316 (67%)	91.08 (70.89, 117.02)
AUC(0,∞) (ng ml−1 h) mean (CV%)†	361 (47%)	328 (70%)	100.98 (93.99, 108.48)
t1/2 (h) mean (CV%)†	4.57 (39%)	3.70 (42%)	NA

^†Unadjusted geometric mean.