Table 5.

Summary of repeated measures analysis of core body temperature AUEC(0,12 h)

	XEN-D501 vs. placebo
	Day 1	Day 2	Day 7	Day 14
Cohort 1: 1 mg twice daily vs. placebo
Treatment difference	3.39	4.68	−0.29	1.80
95% CI	1.80, 4.98	2.90, 6.45	−2.08, 1.51	0.10, 3.50
P value	<0.0001	<0.0001	0.75	0.04
Cohort 2: 2.5 mg twice daily vs. placebo
Treatment difference	5.70	5.65	2.29	2.22
95% CI	4.45, 6.95	4.27, 7.04	1.01, 3.56	0.94, 3.51
P value	<0.0001	<0.0001	0.0006	0.0010
Cohort 3: 5 mg twice daily vs. placebo
Treatment difference	8.86	6.12	3.75	2.92
95% CI	7.50, 10.22	4.73, 7.51	2.35, 5.15	1.56, 4.28
P value	<0.0001	<0.0001	<0.0001	<0.0001