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. Author manuscript; available in PMC: 2012 Sep 2.
Published in final edited form as: Cell Stem Cell. 2011 Sep 2;9(3):193–204. doi: 10.1016/j.stem.2011.08.007

Figure 2. A dual role for TET1 and 5hmC in transcriptional regulation.

Figure 2

A) Schematic of TET1 binding profile in the genome of mouse ESCs. TET1 is most highly enriched at the transcriptional start site (TSS) of genes with high CpG promoters (HCPs) compared to those with intermediate and low CpG promoters (ICPs and LCPs, respectively). B) TET1 directly binds to the co-repressors Sin3a and HDACs. TET1 target genes co-bound by polycomb repressor complex (PRC) proteins and Sin3a are repressed and display bivalent H3K4me3 and H3K27me3 marks. C) TET1-only target genes are actively transcribed and enriched for H3K4me3 and H3K36me3.