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. Author manuscript; available in PMC: 2011 Dec 22.
Published in final edited form as: J Thromb Haemost. 2009 May 8;7(7):1163–1171. doi: 10.1111/j.1538-7836.2009.03476.x

Fig. 5.

Fig. 5

Schematic of 5-hydroxytryptamine (5-HT) actions in platelets. After uptake by 5-HT transporter (SERT) in resting platelets, 5-HT is stored in dense granules, from which it is released upon activation. High intracellular 5-HT concentrations, together with platelet activation by other agonists, leads to serotonylation of small GTPases and α-granule release. Binding of 5-HT to membrane 5-HT receptor (5-HT2AR) activates tumor necrosis factor-alpha-converting enzyme (TACE) and leads to shedding of glycoprotein (GP)Ibα and GPV, which is mediated by p38 mitogen-activated protein kinase (MAPK) and is independent of G-protein signaling. Known 5-HT actions in gray; +, stimulation; −, inhibition. DOI, (−)-2,5-dimethoxy-4-iodoamphetamine hydrochloride.