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. Author manuscript; available in PMC: 2011 Dec 22.
Published in final edited form as: Chembiochem. 2010 Sep 3;11(13):1889–1895. doi: 10.1002/cbic.201000358

Figure 4.

Figure 4

TROL is sensitive to prefibrillar forms of several amyloidogenic proteins The TROL assay was conducted with four amyloid-forming proteins. For each experiment, ThT and TROL fluorescence was recorded side-by-side. TROL reacts with all four amyloids and the signal dramatically decreases in the presence of A) CsgA (25 μM), B) hIAPP/amylin (20 μM), and C) ataxin-3 (10 μM). D) TROL fluorescence is not responsive to the presence of α-synuclein throughout the entire time-course. Each data point is the average of three experiments. Error bars represent the standard deviation and are often smaller than the data symbols. For each data set, results were fit to arbitrary sigmoidal or linear curves only to facilitate visual interpretation.