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. Author manuscript; available in PMC: 2012 Sep 6.
Published in final edited form as: Biochemistry. 2011 Aug 9;50(35):7684–7693. doi: 10.1021/bi2010448

Figure 7.

Figure 7

Comparison of the differential impact of GSH/GSO3 - binding on the kinetics of backbone H/D exchange of MGST1•GSH vs. MGST1•1 (left) and MPGES1•GSH vs. MPGES1•1 (right) and the location of the GSH binding site in the proteins as defined by 3D electron diffraction from 2D crystals.7,25 The dotted lines indicate the approximate location of the cytosolic (top) and luminal (bottom) boundaries of the microsomal membrane. The tan helical regions highlight the differential effects of GSH and GSO3 - on the H/D exchange kinetics.