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. Author manuscript; available in PMC: 2012 Sep 6.

Published in final edited form as: Biochemistry. 2011 Aug 9;50(35):7684–7693. doi: 10.1021/bi2010448

Definition of the leukotriene substrate-binding site. (A) In LTC4S by co-crystallization with GSH in the presence of the detergent n-dodecyl-β-D-maltoside. The DDM and GSH molecules are shown in stick representation. DDM is thought to reside in the leukotriene A₄ binding site. (B) In MPGES1 through structural comparison of LTC4S with MPGES1. The GSH molecule is shown in stick representation. (C) In MPEGS1 by H/D exchange kinetics in the presence of inhibitors 2, 3 and 4. The GSH molecule and the side chains of T131, L135 and A138 in helix IV are shown in stick representation.

Definition of the leukotriene substrate-binding site. (A) In LTC4S by co-crystallization with GSH in the presence of the detergent n-dodecyl-β-D-maltoside. The DDM and GSH molecules are shown in stick representation. DDM is thought to reside in the leukotriene A₄ binding site. (B) In MPGES1 through structural comparison of LTC4S with MPGES1. The GSH molecule is shown in stick representation. (C) In MPEGS1 by H/D exchange kinetics in the presence of inhibitors 2, 3 and 4. The GSH molecule and the side chains of T131, L135 and A138 in helix IV are shown in stick representation.