Table 2. Immune response pathways in animals housed in different environments at day 5, 28 and 56.
| Regulatory processes/Immune response | P-Value | Sign.* | Total** |
| OIs vs InIs Day 5 | 13 | 34 | |
| Immune response_Alternative complement pathway | 6.732E-06 | 11 | 26 |
| Immune response_Antigen presentation by MHC class I | 0.00001 | 11 | 34 |
| Immune response_Antiviral actions of Interferons | 0.00020 | 12 | 43 |
| Immune response_Lectin induced complement pathway | 0.00050 | 12 | 45 |
| Immune response_Classical complement pathway | 0.00078 | 8 | 24 |
| Immune response_IFN alpha/beta signaling pathway | 0.00123 | 12 | 59 |
| Chemotaxis_Leukocyte chemotaxis | 0.00883 | 8 | 33 |
| Immune response_IL-22 signaling pathway | 0.01076 | 6 | 22 |
| Immune response_IL-23 signaling pathway | 0.01474 | 7 | 31 |
| Immune response_MIF - the neuroendocrine-macrophage connector | 0.02441 | 7 | 31 |
| * Immune response_Th17 cell differentiation | 0.02441 | 9 | 48 |
| Immune response _Immunological synapse formation | 0.03588 | 5 | 20 |
| Neurophysiological process_PGE2-induced pain processing | 0.03650 | 8 | 41 |
| Apoptosis and survival_Lymphotoxin-beta receptor signaling | 0.03775 | 7 | 34 |
| Immune response_TCR and CD28 co-stimulation in activation of NF-kB | 0.03897 | 6 | 28 |
| Immune response_HTR2A-induced activation of cPLA2 | 0.04569 | 13 | 34 |
| OIs vs InIs Day 28 | |||
| Immune response_IL-3 activation and signaling pathway | 0.01165 | 5 | 30 |
| Immune response_Antigen presentation by MHC class II | 0.01260 | 3 | 11 |
| Immune response_Role of the Membrane attack complex in cell survival | 0.02715 | 4 | 25 |
| OIs vs InIs Day 56 | |||
| Immune response_ICOS pathway in T-helper cell | 0.00129 | 8 | 37 |
| Immune response_Antigen presentation by MHC class II | 0.00303 | 4 | 11 |
| Immune response_NFAT in immune response | 0.00304 | 8 | 42 |
| Immune response_Antigen presentation by MHC class I | 0.00372 | 6 | 26 |
| Immune response_NF-AT signaling and leukocyte interactions | 0.00667 | 7 | 38 |
| Immune response _CCR3 signaling in eosinophils | 0.00798 | 9 | 59 |
| Immune response_TCR and CD28 co-stimulation in activation of NF-kB | 0.01453 | 6 | 34 |
| Chemotaxis_Lipoxin inhibitory action on fMLP-induced neutrophil chemotaxis | 0.01453 | 6 | 34 |
| Chemotaxis_Inhibitory action of lipoxins on IL-8- and Leukotriene B4-induced neutrophil migration | 0.01668 | 6 | 35 |
| Immune response_T cell receptor signaling pathway | 0.01676 | 7 | 45 |
| Immune response_MIF - the neuroendocrine-macrophage connector | 0.03578 | 5 | 31 |
| Immune response_Function of MEF2 in T lymphocytes | 0.03804 | 6 | 42 |
| Immune response_CD28 signaling | 0.04207 | 6 | 43 |
| Immune response_Regulation of T cell function by CTLA-4 | 0.04536 | 5 | 33 |
Differentially expressed genes (P<0.05) were imported into GeneGo MetaCore analytical software to determine the significantly enriched immune response pathways.
*The number of genes on each map that are differentially expressed in the specific treatment comparison.
**The total number of genes on each map.