Table 1.
Chromosomal copy number alterations. Red and green areas indicate DNA gains and losses, respectively. Aberrations were obtained with ADM2 algorithm and filtering options of a minimum of five probes and log2 (ratio) > 0.25. Genomic coordinates according to the mm9 build (July 2007) and values in log2 (ratio).
| Genomic coordonates (mm9) | chromosome | band | ASTRO | ASTRO + TGFα | IRRADIATED ASTRO + TGFα ADHERENT CELLS | IRRADIATED ASTRO + TGFα FLOATING CELLS | TUMOR 1 FROM IRRADIATED ASTRO + TGFα ADHERENT CELLS | TUMOR 2 FROM IRRADIATED ASTRO + TGFα ADHERENT CELLS | TUMOR 3 FROM IRRADIATED ASTRO + TGFα ADHERENT CELLS | TUMOR 4 FROM IRRADIATED ASTRO + TGFα ADHERENT CELLS | TUMOR 5 FROM IRRADIATED ASTRO + TGFα ADHERENT CELLS | TUMOR 1 FROM IRRADIATED ASTRO + TGFα FLOATING CELLS | TUMOR 2 FROM IRRADIATED ASTRO + TGFα FLOATING CELLS | TUMOR 3 FROM IRRADIATED ASTRO + TGFα FLOATING CELLS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| chr2:81139123-101306651 | 2 | 2qD-E1 | 0 | 0 | −0.28 | 0 | − 0.25 | − 0.26 | 0 | 0 | 0 | − 0.27 | 0 | 0 |
| chr2:115846031-123819240 | 2 | 2qE5 | 0.84 | 0.86 | 1.04 | 0.92 | 0.78 | 0.87 | 0.83 | 0.82 | 0.78 | 0.69 | 0.78 | 0.84 |
| chr3:83835375-93096260 | 3 | 3qF1 | 0 | 0 | 0 | 0.3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| chr4:109852334-116510051 | 4 | 4qD1 | 2.65 | 2.63 | 2.38 | 2.42 | 2.12 | 2.44 | 0 | 0 | 2.25 | 2.19 | 2.46 | 0 |
| chr4:132678793-140287612 | 4 | 4qD3 | 0 | 0 | 0 | 0 | −0.54 | −0.47 | −0.58 | 0 | −0.49 | −0.43 | −0.49 | −0.55 |
| chr4:140287612-146469778 | 4 | 4qE1 | 0 | 0 | 0 | 0.48 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| chr4:146469778-155029701 | 4 | 4qE2 | 0 | 0.08 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| chr5:81773799-91394246 | 5 | 5qE1 | 0 | 0 | −0.26 | 0 | −0.25 | −0.28 | 0 | 0 | −0.24 | 0 | 0 | 0 |
| chr6:0-16613965 | 6 | 6qA1 | 0 | 0 | −1.02 | −1.03 | −0.77 | −0.85 | −0.79 | −0.84 | −0.81 | −0.61 | −0.77 | −0.85 |
| chr6:16613965-116786401 | 6 | 6qA2-E3 | 0 | 0 | 0.29 | 0.43 | 0.33 | 0.36 | 0.37 | 0.38 | 0.36 | 0.29 | 0.35 | 0.39 |
| chr6:125093383-139264118 | 6 | 6qF3-G1 | 0 | 0 | −0.27 | −0.27 | −0.31 | −0.31 | −0.25 | 0 | −0.25 | −0.24 | 0 | 0 |
| chr7:0-15170811 | 7 | 7qA1 | 0 | 0 | 0.3 | 0.3 | 0.26 | 0.24 | 0.34 | 0.3 | 0.28 | 0 | 0.22 | 0 |
| chr7:15170811-37421334 | 7 | 7qA2-B2 | 0 | 0 | 0.36 | 0.45 | 0.26 | 0.31 | 0.34 | 0.3 | 0.28 | 0 | 0.28 | 0.25 |
| chr7:37421334-47535208 | 7 | 7qB3 | 0 | 0 | 0.43 | 0.45 | 0.33 | 0.31 | 0.34 | 0.36 | 0.34 | 0 | 0.28 | 0.25 |
| chr7:47535208-54109226 | 7 | 7qB4 | 0 | 0 | 0.3 | 0.3 | 0.26 | 0 | 0.34 | 0 | 0 | 0 | 0 | 0 |
| chr7:54109226-60683244 | 7 | 7qB5 | 0 | 0 | 0.3 | 0.3 | 0 | 0 | 0.34 | 0 | 0 | 0 | 0 | 0 |
| chr7:60683244-71302812 | 7 | 7qC | −0.72 | 0.3 | −0.68 | −0.4 | 0.26 | −0.42 | 0.34 | −0.36 | −0.4 | −0.69 | −0.45 | −0.5 |
| chr7:71302812-90013479 | 7 | 7qD1-D3 | 0 | 0 | 0.3 | 0.22 | 0.26 | 0.24 | 0.34 | 0.3 | 0.28 | 0 | 0 | 0 |
| chr7:90013479-102150128 | 7 | 7qE1-E2 | 0 | 0 | 0.3 | 0.22 | 0.26 | 0 | 0.34 | 0.3 | 0.28 | 0 | 0 | 0 |
| chr7:102150128-111252615 | 7 | 7qE3 | 0 | 0 | 0.3 | 0.22 | 0.26 | 0.24 | 0.34 | 0.3 | 0.28 | 0 | 0.22 | 0 |
| chr7:111252615-145134094 | 7 | 7qF1-F5 | 0 | 0 | 0.3 | 0 | 0.26 | 0 | 0.34 | 0.3 | 0.28 | 0 | 0 | 0 |
| chr9:14343360-24059831 | 9 | 9qA2-A3 | 0 | 0 | 0 | 0 | −0.32 | −0.33 | 0 | 0 | 0 | 0 | 0 | 0 |
| chr10:23539770-41194597 | 10 | 10qA4-B1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | −0.27 | −0.27 | 0 |
| chr10:41194597-63753544 | 10 | 10qB2-B4 | 0 | 0 | −0.3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| chr10:95630316-111323496 | 10 | 10qC3-D1 | 0 | 0 | −0.28 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| chr11:62758837-121798632 | 11 | 11qB3-E2 | 0 | 0 | 0.52 | 0.5 | 0.42 | 0.45 | 0.43 | 0.44 | 0.43 | 0.37 | 0.42 | 0.45 |
| chr14:43144646-51575209 | 14 | 14qC1 | 0 | 0 | −0.24 | 0 | −0.31 | −0.32 | 0 | 0 | 0 | 0 | 0 | 0 |
| chr14:51575209-54550702 | 14 | 14qC2 | 0.62 | 0.63 | 0.56 | 0.55 | 0.53 | 0.51 | 0.55 | 0.55 | 0.57 | 0.5 | 0.56 | 0.58 |
| chr14:59509857-68436336 | 14 | 14qD1 | 0 | 0.83 | 0.36 | 0.44 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| chr15:0-66107593 | 15 | 15qA1-D1 | 0 | 0 | 0.35 | 0 | 0.31 | 0.35 | 0.39 | 0.43 | 0.36 | 0.31 | 0.43 | 0.52 |
| chr15:66107593-103492577 | 15 | 15qD2-F3 | 0 | 0 | 0.43 | 0 | 0.39 | 0.44 | 0.39 | 0.43 | 0.42 | 0.39 | 0.49 | 0.59 |
| chr17:21829683-31434744 | 17 | 17qA3.3 | −0.5 | −0.54 | −0.56 | −0.51 | −0.53 | −0.49 | −0.53 | −0.49 | −0.53 | −0.49 | −0.53 | −0.56 |
| chr19:0-16650124 | 19 | 19qA | 0 | 0 | −0.99 | −0.99 | −0.67 | −0.7 | −0.76 | −0.81 | −0.73 | 0.3 | −0.67 | −0.78 |
| chr19:38173456-61321190 | 19 | 19qC3-D3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.21 | 0 | 0 |