Figure 1. Apc heterozygosity accelerates MMTV-PyMT-mediated mammary tumorigenesis with no effect in the MMTV-c-Neu model.

Experimental (MMTV-PyMT;Apc^Min/+ (n = 35 for survival and n = 13 for latency) and MMTV-c-Neu;Apc^Min/+ (n = 13)) and control (MMTV-PyMT;Apc^+/+ (n = 37 for survival and n = 15 for latency) and MMTV-c-Neu;Apc^+/+ (n = 15)) mice were palpated bi-weekly for tumor development. For the survival study, animals were sacrificed when the tumor reached 10% of the animal's body weight or became ulcerated. Kaplan-Meier curves for MMTV-PyMT tumor studies demonstrate that both (A) survival and (B) latency have a significant shift to the left in the presence of the Apc^Min/+ mutation. However, Kaplan-Meier curves for (C) survival and (D) latency show no change in the MMTV-c-Neu model with introduction of the Apc^Min/+ mutation. Median values are given, and significance was determined using the Wilcoxon test.