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. 2011 Dec 22;6(12):e29130. doi: 10.1371/journal.pone.0029130

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Dodd et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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If the reduction in case load over the intervention is large enough to mean the treatments save (more than) pay for the case-finding rounds then the intervention saves the health system money. This happens for a high enough initial burden, and for a low enough cost per round relative to the cost of treatment (hatched regions). We have factored out efficiency to allow for approximate comparison between screening strategies of different efficiency. The HIV prevalence in incident TB, , makes some difference; but the most influential factors in determining these regions are the initial case detection rates () and the initial proportion recent ().

Inline graphic — If the reduction in case load over the intervention is large enough to mean the treatments save (more than) pay for the case-finding rounds then the intervention saves the health system money. This happens for a high enough initial burden, and for a low enough cost per round relative to the cost of treatment (hatched regions). We have factored out efficiency to allow for approximate comparison between screening strategies of different efficiency. The HIV prevalence in incident TB, , makes some difference; but the most influential factors in determining these regions are the initial case detection rates () and the initial proportion recent ().