Table 3. Characteristics of male subjects.
| Cohort 1 - ‘suspected CAD’ | Cohort 2 - ‘myocardial infarction’ | Cohort 3 - ‘LMCAD’ | |||||||
| Significance | Significance | Significance | |||||||
| Parameter | Men | No CAD | CAD<50% | CAD≥50% | No CAD vs. CAD≥50% | Men | vs. CAD≥50% | Men | vs CAD≥50% |
| n | 1457a | 405 (28) | 311 (22) | 680 (47 ) | 438 | 242 | |||
| Age (years) | 61.0±11.2 | 57.6±11.4 | 63.3±10.6 | 63.5±10.6 | <0.001 | 59.4±12.2 | <0.001 | 68.6±9.5 | <0.001 |
| BMI | 29.6±4.7 | 29.8±4.9 | 29.9±5.3 | 29.4±4.2 | ns | 28.6±4.2 | <0.001 | 28.3±4.1 | 0.002 |
| Diabetes | 431 (30) | 87 (21) | 119 (38) | 216 (32) | <0.001 | 88 (20) | <0.001 | 105 (43) | <0.001 |
| Smoker (former/current) | 756/298 (52/21) | 220/71 (54/18) | 170/63 (54/20) | 350/149 (52/22) | ns | 127/215 (29/49) | <0.001 | 154/30 (63/12) | <0.001 |
| Family history | 415 (29) | 102 (25) | 76 (25) | 219 (32) | 0.047 | 153 (35) | ns | 80 (33) | ns |
| SBP/DBP (mmHg) | 139/84 | 137/86 | 141/84 | 140/83 | 0.043/0.001 | ||||
| Gensini score | 20.1±29.4 | 0.0 | 2.7±2.7 | 39.9±31.7 | <0.001 | 44.4±29.6 | |||
| Total-C | 5.60±1.17 | 5.50±1.10 | 5.53±1.08 | 5.67±1.24 | 0.013 | 5.11±1.08 | 0.001 | 4.44±1.04 | <0.001 |
| HDL-C | 1.18±0.34 | 1.23±0.35 | 1.18±0.37 | 1.16±0.33 | 0.008 | 1.17±0.32 | ns | 1.12±0.31 | 0.046 |
| LDL-C | 3.62±1.06 | 3.45±0.96 | 3.53±0.97 | 3.75±1.13 | <0.001 | 3.10±0.97 | <0.001 | 2.55±0.83 | <0.001 |
| TG | 1.81±1.70 | 1.84±2.43 | 1.78±1.46 | 2.10±1.29 | ns | 1.74±1.09 | <0.001 | 1.82±1.25 | 0.005 |
| hsTroponin T ng/l | 13 (0–2650) | 11 (0–1780) | 11 (0–480) | 14 (0–2650) | <0.001 | 1574 (10–38280) | <0.001 | 18 (0–4330) | ns |
| Nt-proBNP | 170±1207 | 110±1496 | 157±1132 | 228±1035 | ns | 1649±5006 | <0.001 | 497±4083 | <0.001 |
| hsCRP mg/l | 2.4±11.3 | 1.9±9.0 | 2.4±10.4 | 2.7±12.8 | 0.013 | 43±61 | <0.001 | 3.0±9.3 | ns |
| % ASA | 52 | 41 | 49 | 60 | <0.001 | 12 | <0.001 | 87 | <0.001 |
| % RAAS blocker | 69 | 62 | 77 | 70 | 0.026 | 31 | <0.001 | 93 | <0.001 |
| % Beta blocker | 54 | 51 | 52 | 56 | ns | 19 | <0.001 | 90 | <0.001 |
| % Ca antagonist | 23 | 17 | 28 | 25 | 0.011 | 10 | <0.001 | 28 | ns |
| % Diuretic | 37 | 32 | 42 | 37 | ns | 8 | <0.001 | 59 | <0.001 |
| % Statin | 35 | 27 | 36 | 39 | <0.001 | 12 | <0.001 | 82 | <0.001 |
BMI, body-mass index in kg/m2; SBP/DBP, systolic and diastolic blood pressure in mmHg; Total-C/HDL-C/LDL-C, cholesterol in mmol/l; hsCRP, high sensitive C-reactive protein in mg/l; RAAS, renin-angiotensin-aldosterone-system; ASA, acetylsalicylic acid. Values are given as arithmetic mean ± standard deviation for normally distributed parameters, geometric mean ± standard deviation for non normal distributed parameters or as percent of subjects for categorical items. Statistic differences between no CAD and CAD ≥50 were calculated using Students t-test/Kruskal-Walis test for scaled items and Chi-square test for categorical items. a including 61 men without angiography.