Figure 7. In combination with our previous report [5], we have created an overview of the early molecular response comparing woven to lamellar bone formation.

There is an early immune response that persists through time but tends to decrease in expression. The vascular response is also a major component of woven bone formation and it precedes osteogenesis. Osteogenic indicators are differentially regulated shortly after loading, but seem to increase over time. Finally, bone remodeling markers are activated later, possibly to repair bone damage. Gene expression changes likely persist through many weeks after loading, but our data only includes early timepoints after loading.