Table 1. Main characteristics of the 80 HIV-infected MSM at acute HCV infection diagnosis reported by physicians, medical questionnaire, HEPAIG study, 2006–2007.
Region of care | Paris area | 48 (60.0) |
Age, years | 40 (36–44) | |
Year of HCV diagnosis | 2006 | 41 (51) |
2007 | 39 (49) | |
Year of HIV diagnosis | <1996 | 30 (37.5) |
1996–1999 | 14 (17.5) | |
≥2000 | 36 (45.0) | |
Time between HIV and HCV diagnosis, years | 9 (3–13.5) | |
HIV clinical stage | primary infection | 2 (2.5) |
asymptomatic | 58 (72.5) | |
symptomatic | 12 (15.0) | |
AIDS-defining illness | 8 (10.0) | |
HIV viral load | undetectablea under HAART | 46 (57.5) |
detectable without HAART | 22 (26.2) | |
detectable under HAART | 10 (12.5) | |
missing | 2 (2.5) | |
CD4 cell count/mm3 | >500 | 46 (57.5) |
350–500 | 20 (25.0) | |
200–349 | 11 (13.7) | |
<200 | 3 (3.8) | |
Circumstances of HCV diagnosisb | systematic anti-HCV screening | 17 (21.2) |
increased ALT level | 62 (77.5) | |
at risk behaviour | 27 (33.7) | |
jaundice | 9 (11.2) | |
Concomitant diagnosis of STI | yes | 29 (36.2) |
no | 43 (53.8) | |
missing | 8 (10.0) | |
Acute HCV infection | confirmedc | 59 (74.0) |
possibled | 16 (20.0) | |
re-infectione | 5 (6.0) | |
ALT level, xULN | ≤1 | 6 (7.5) |
>1–<3 | 10 (12.5) | |
3–5 | 14 (17.5) | |
>5–7 | 8 (10.0) | |
>7–10 | 4 (5.0) | |
>10 | 35 (43.7) | |
not available | 3 (3.7) | |
HCV viral load,log10, IU/mL | 5.9(5.1–6.5) | |
HCV genotype | 1 | 26 (32.5) |
3 | 8 (10.0) | |
4 | 44 (55.0) | |
not available | 2 (2.5) |
Note. Data are no. (%) of patients or median values (inter-quartile range); MSM, men who have sex with men; HAART, highly active antiretroviral treatment; STI, sexually transmitted infection; ALT, alanine aminotransferase; ULN, upper limit of normal; a<50 copies/mL; bseveral possible answers; canti-HCV (+) within one year after anti-HCV (-) or HCV RNA (+) within one year after both documented anti-HCV (-) and HCV RNA (-); dHCV RNA (+) either: i) within one year after two documented HCV RNA (-), or, ii) with symptoms of acute hepatitis and ALT level >10xULN within one year after regular controls of normal ALT (other causes excluded); epossible acute HCV infection following primary infection with confirmed viral clearance.