Table 2. Genes shared between P. falciparum and P. vivax but absent in P. knowlesi.
| PfGene (PvPID/OG) | Product | RNA-seq. expr. (IDC) | Protein expr. | Additional information |
| PFI1405c(44/RODE) | unknown function | Min: 15 hMax: 25 h | TZ; iRBCm | C-terminal TM (InterProScan); antigenic variation (PlasmoDraft) |
| MAL8P1.126(35/ALVE) | serine protease, putative | Min: 10 hMax: 35 h | oocyst SZ | Deg2 chloroplast peptidase (MEROPS); sole member of clan PA/family S1; SP |
| PF14_0454(23/RODE) | unknown function | Min: 10 hMax: 35 h | SZ;TZ; (el)GC | calponin-like actin-binding; winged-helix DNA binding; defense response (PlasmoDraft) |
| PF11_0460(19/RODE) | unknown function | Min: 20 hMax: 35 h | GC; MZ; eStages | upregulated in GC |
| PFL0170w(19/RODE) | transporter, putative | Min: 20 hMax: 35 h | (l)GC; TZ | 12 TM; MFS general substrate transporter |
| PF11_0361-a(55/RODE) | unknown function | Min: 20 hMax: 35 h | - | 6 TM; PQ-loop repeat; SP |
| PF11_0134(52/RODE) | unknown function | Min: 20 hMax: 35 h | - | TM; DUF1704 member (conserved in many species) |
| MAL13P1.107(34/----) | unknown function | Min: 20 hMax: 35 h | SZ; (l)GC | SP and GPI-anchor; similarity with neighboring rhoptry protein 2 (PF13_0116) |
| PFL0360c(8/----) | unknown function | Min: 25 hMax: 35 h | - | 3 TM; ZF; divergent Pv positional ortholog; similar to serine protease (PlasmoDB) |
| PF14_0236(12/----) | unknown function | Min: 25 hMax: 35 h | SZ; MZ | ZF; divergent Pv positional ortholog; antigenic variation (PlasmoDraft); upregul. in GC |
| PFI1216w(52/RODE) | telomeric repeat binding factor 1 | Min: -Max: - | - | homeodomain-like; SANT, DNA binding; MYB-like; EST support |
| PFA0380w(10/RODE) | serine/threonine kinase, putative | Min: -Max: - | SZ | N-terminal TM; divergent Pv positional ortholog; EST support; upregulated in SZ |
| PF10_0185(28/RODE) | unknown function | Min: -Max: - | - | EST support; upregulated in GC |
Shown are all P. falciparum genes that were found to have a syntenic ortholog in the second human parasite P. vivax but no identifiable ortholog (neither syntenic nor non-syntenic) in the monkey parasite P. knowlesi. Four of these genes (MAL8P1.126, MAL13P1.107, PFL0360c, and PF14_0236) also lack an identifiable ortholog in the three rodent parasite genomes and are thus potentially unique to human Plasmodium parasites. Genes ordered and grouped by similarity of their IDC expression profile (see legend Table 1). A table with graphical RNA-seq expression profiles for these genes is provided in Table S10. Abbreviations: Pf: P. falciparum; Pv: P. vivax; PvPID: global protein sequence identity with P. vivax ortholog; OG: closest OrthoMCL DB species out-group with predicted ortholog of this gene; ALVE: Alveolates; RODE: rodent malaria parasites; iRBCm: infected red blood cell membrane (PIESPs)/Schizont; SZ: sporozoites; (el)GC: (early/late) gametocytes; TZ: trophozoite; MZ: merozoites; SC: schizont; ZF: zinc finger domain; TM: predicted transmembrane domain; SP: predicted signal peptide.