Table 5. Transition states (expression levels) during reprogramming using the five experimental recipes.
Gene | DifferentiationAttractor | DifferentiationBarrier | Valley at step(2,3,4) | hES Barrier Climb at 3,4,5 | hES Valley at step 4,5,6,7,8 | hES Attractor at step 4,5,6,7,8 |
OCT4 | 0 | 1 | 1 | 1 | 1 | 1 |
SOX2 | 0 | 1 | 1 | 1 | 1 | 1 |
NANOG | 0 | 0 | 0 | 1 | 1 | 1 |
Oct4-Sox2 | 0 | 0 | 1 | 1 | 1 | 1 |
KLF4 | 0 | 0.5 | 1 | 1 | 1 | 1 |
FOXD3 | 0 | 0 | 0.6161 | 0.5172 | 1 | 1 |
ZIC3 | 0 | 0 | 0.5094 | 0.4721 | 1 | 1 |
ZFP42 | 0 | 0 | 0.5248 | 0.4893 | 1 | 1 |
GDF3 | 0 | 0 | 0 | 0 | 1 | 1 |
TDGF1 | 0 | 0 | 1 | 1 | 1 | 1 |
PBX1 | 0 | 0 | 0 | 0 | 1 | 1 |
GATA2 | 1 | 1 | 0.4883 | 0.4893 | 0.2075 | 0 |
GATA3 | 1 | 1 | 1 | 1 | 0 | 0 |
hCGb | 1 | 1 | 0 | 0 | 0 | 0 |
hCGa | 1 | 1 | 0.4415 | 0.368 | 0.3774 | 0 |
CDX2 | 1 | 1 | 1 | 1 | 0 | 0 |
GATA4 | 1 | 1 | 0.6475 | 0.5043 | 0 | 0 |
GATA6 | 1 | 1 | 0.3577 | 0 | 0 | 0 |
FOXA2 | 1 | 1 | 0.5927 | 0.6352 | 0.3774 | 0 |
AFP | 1 | 1 | 0.5779 | 0.441 | 0.4528 | 0 |
SOX17 | 1 | 1 | 0.4119 | 0.3509 | 0.3774 | 0 |
T | 1 | 1 | 0.4313 | 0.4506 | 0 | 0 |